| Name | Phone | Category |
| Saddoris & Associates, P.C. | (515) 965-5663 | Finance |
| Sands Chiropractic | (515) 984-6484 | Health Care |
| Saylorville Baptist Church | (515) 289-2395 | Religious Affiliations |
| Schaal Heating & Cooling | (515) 288-3631 | Contractor |
| Scornovacca's Pizza Corp. | (515) 266-5703 | Restaurants |
| Screenbuilders | (515) 289-2790 | Contractor |
| Secure Storage | (515) 299-9230 | Storage |
| Septagon Construction, Inc. | (515) 986-7313 | Contractor |
| ServiceMaster 380 | (515) 964-3239 | Cleaning-Maintenance |
| Shear Style Salon | (515) 964-1388 | Health & Beauty |
| Sherwin - Williams | (515) 964-7890 | Retail-Shops-Stores |
| Shirt Works | (515) 289-0456 | Advertising |
| Shive-Hattery, Inc. | (515) 223-8104 | Design Services |
| Siemens Industry | (515) 963-1400 | Security-Safety |
| Signs Plus, Inc. | (515) 285-8700 | Retail-Shops-Stores |
| Silliman Construction Co. | (515) 964-2315 | Contractor |
| Silver Printing & Promotions | (515) 963-7880 | Advertising |
| Simply Cheesecakes & Such | (515) 964-7144 | Food-Beverage |
| Simply Tantastic, Inc. | (515) 963-9003 | Health & Beauty |
| Simpson College Evening, Weekend and Graduate Programs | (515) 965-9355 | Education |
| Skeffington's Formal Wear | (515) 964-3490 | Retail-Shops-Stores |
| Skinner's Carpet Cleaning, Inc. | (515) 964-3745 | Cleaning-Maintenance |
| Slumberland | (515) 965-5361 | Retail-Shops-Stores |
| Small Business Resources, L.C. | (515) 964-4977 | Finance |
| Smart Cleaning & Maintenance | (515) 331-8940 | Cleaning-Maintenance |
| Smashburger | (515) 963-5100 | Restaurants |
| Smith's Body & Paint, Inc. | (515) 964-1094 | Automotive |
| Smokey D's BBQ | (515) 243-2747 | Food-Beverage |
| Smoldt Moving & Storage, Inc. | (515) 964-9690 | Moving |
| Snyder & Associates, Inc. | (515) 964-2020 | Design Services |
| Soil and Water Conservation Society | (515) 289-2331 | Organizations |
| Sonic Drive-In | (515) 963-0399 | Restaurants |
| Sonja Chesnik Interiors | (515) 577-6035 | Design Services |
| South Ankeny Mini Storage | (515) 964-0778 | Storage |
| South Story Bank & Trust | (515) 228-3566 | Finance |
| Spahr, Roger | (515) 964-4330 | Individual Membership |
| SPAL USA, Inc. | (515) 289-7000 | Distributors |
| Spirit Boulevard | (515) 964-0074 | Retail-Shops-Stores |
| Splash Car Wash | (515) 965-1501 | Automotive |
| Sportsman's Warehouse | (515) 963-3500 | Retail-Shops-Stores |
| Spring Valley Wireless | (515) 964-2888 | Communications |
| Springer Professional Home Services | (515) 262-9229 | Environmental |
| Springwood 9 Theatre | (515) 964-7887 | Entertainment-Recreation |
| St. Anne's Episcopal Church | (515) 964-5152 | Religious Affiliations |
| St. Paul Lutheran Church | (515) 964-1250 | Religious Affiliations |
| Stable Ground, LLC | (515) 230-4020 | Human Services |
| State Farm Insurance - Brian Hoff | (515) 965-1900 | Insurance-Finance |
| State Farm Insurance - Deb Stubbs | (515) 964-9500 | Insurance-Finance |
| State Farm Insurance - Ken Nelson | (515) 964-4052 | Insurance-Finance |
| State Farm Insurance - Nate Sammler | (515) 964-8102 | Insurance-Finance |
| Steve Gibbons Photography | (515) 964-7591 | Photography |
| STIX | (515) 963-3353 | Entertainment-Recreation |
| Strauss Security Solutions | (515) 276-7030 | Security-Safety |
| Strawberry Patch | (515) 964-3555 | Retail-Shops-Stores |
| Struthers Bros. Kawasaki-Suzuki, Inc. | (515) 282-3634 | Retail-Shops-Stores |
| StruXture Architects | (515) 283-5101 | Design Services |
| Studio A Designs | (515) 783-5937 | Design Services |
| Sunbelt Business Brokers | (515) 964-5431 | Business Services |
| Sunny View Care Center | (515) 964-1101 | Health Care |
| Super Target | (515) 964-9000 | Retail-Shops-Stores |
| Superior Lighting, Inc. | (800) 761-5267 | Contractor |
| Sylvan Learning Center | (515) 867-8000 | Education |
| Sysco Iowa, Inc. | (515) 289-5300 | Distributors |