| Name | Phone | Category |
| R & T Performance Glass | (515) 964-1580 | Automotive |
| RCS Millwork, L.C. | (515) 289-3787 | Contractor |
| RDG Planning & Design | (515) 288-3141 | Design Services |
| RE/MAX Opportunities Inc. - White Birch Office | (515) 965-5071 | Real Estate |
| RE/MAX Opportunities, Inc | (515) 964-9400 | Real Estate |
| RE/MAX Opportunities, Inc. - Bonnie Christensen | (515) 971-9973 | Real Estate |
| RE/MAX Opportunities, Inc. - Lynette Dyer | (515) 250-1155 | Real Estate |
| RE/MAX Opportunities, Inc. - Natalie Kimberley | (515) 321-9398 | Real Estate |
| Real Life Church | (515) 963-0088 | Religious Affiliations |
| ReNu Your Smile | (515) 963-6505 | Health & Beauty |
| Renze Chiropractic Clinic | (515) 965-3844 | Health Care |
| Resistance Skate Shop | (515) 964-5444 | |
| Resurrection Lutheran Church | (515) 964-7392 | Religious Affiliations |
| Revolutions, A Twirling Academy, LLC | (515) 975-3317 | Entertainment-Recreation |
| Ripley Company, LLC | (515) 289-2105 | Retail-Shops-Stores |
| Rising Star Wholesale | (515) 289-5001 | Contractor |
| Rob Tucker Consulting, Ph.D., J. D. | (515) 276-8282 | Business Services |
| Rock Valley Physical Therapy | (515) 964-2559 | Health Care |
| Ronald McDonald House Des Moines | (515) 243-2111 | Organizations |
| Ron's Electric & Plumbing, Inc. | (515) 289-2381 | Contractor |
| Rosa Digital Arts | (515) 865-5470 | Photography |
| RSM McGladrey, Inc. | (515) 558-6600 | Finance |
| Rybolt Consulting, Inc. | (515) 964-5200 | Computer |